Eicosapentaenoic Acid-Enriched High-Density Lipoproteins Exhibit Anti-Atherogenic Properties
نویسندگان
چکیده
منابع مشابه
Anti-atherogenic Functions of High Density Lipoproteins
HDL has many protective activities against atherosclerosis including its role in reverse cholesterol transport, and its antioxidant, anti-inflammatory, and endothelial cell maintenance functions. Various HDL subclasses vary in quantitative and qualitative content of lipids, apolipopropteins, enzymes, and lipid transfer proteins, resulting in differences in shape, density, size, charge, and anti...
متن کاملAMPK activation enhances the anti-atherogenic effects of high density lipoproteins in apoE−/− mice
HDL plays crucial roles at multiple stages of the pathogenesis of atherosclerosis. AMP-activated protein kinase (AMPK) is a therapeutic candidate for the treatment of cardiovascular disease. However, the effect of AMPK activation on HDL functionality has not been established in vivo. We assessed the effects of pharmacological AMPK activation using A-769662, AICAR, metformin, and IMM-H007 on the...
متن کاملHeart failure is associated with impaired anti-inflammatory and antioxidant properties of high-density lipoproteins.
Oxidative stress and inflammation are hallmarks of the heart failure (HF) disease state. In the present study, we investigated the inflammatory/anti-inflammatory characteristics of high-density lipoproteins (HDL) in patients with HF. Ninety-six consecutive patients with systolic HF were followed in an advanced HF center, and 21 healthy subjects were recruited. Plasma was tested for HDL inflamma...
متن کاملAnti-atherogenic and anti-inflammatory properties of high-density lipoprotein are affected by specific antibodies in systemic lupus erythematosus.
OBJECTIVE To determine whether antibodies against high-density lipoprotein (aHDL) and apolipoprotein A-I (aApo A-I) interfere with the anti-atherogenic functions of high-density lipoprotein (HDL) and relate to disease activity and damage in SLE. METHODS Seventy-seven SLE patients were compared with an age- and sex-frequency matched control group. Immunoglobulin G (IgG) aHDL, IgG aApoA-I, solu...
متن کامل[High-density lipoproteins].
the accurate mechanism of how EIIC transports a sugar has not been clearly demonstrated yet. To investigate more detailed and accurate transportation mechanisms, we performed collective variable-based steered molecular dynamics (CVSMD) simulations. Our simulation shows the spontaneous transportation of the sugar toward the opposite side of the membrane with the preserved H-bonding interactions,...
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ژورنال
عنوان ژورنال: Circulation Journal
سال: 2018
ISSN: 1346-9843,1347-4820
DOI: 10.1253/circj.cj-17-0294